Ethnicity-related differences in tumor immunity: a new possible explanation for gastric cancer prognostic variability?

Gastric cancer (GC) is a very heterogeneous disease. Despite the decreasing incidence with time, it represents the second most common cause of cancer-related death after lung cancer; however, it is well known that incidence rates are very different throughout the world, with some geographic areas showing much higher rates than other regions (1,2>). Subtypes of GC present different and sometimes opposite epidemiological trends, with reference to proximal vs. distal tumor locations, or intestinal vs. diffuse Lauren histological types (3).