@article{TGH5665,
author = {Thomas Worland and Ken Lee Chin and Beverley Rodrigues and Amanda Nicoll},
title = {A retrospective case-controlled cohort study of inpatient drug induced liver injury: the RIDDLE study},
journal = {Translational Gastroenterology and Hepatology},
volume = {5},
number = {0},
year = {2020},
keywords = {},
abstract = {Background: Identification of risk factors for drug-induced liver injury (DILI) has been hindered by the unpredictable incidence and idiosyncratic nature of DILI. The aim of this study was to identify characteristic host risk factors for DILI.
Methods: A retrospective cohort study was performed examining all patients admitted with a diagnosis of DILI over a 5.5-year period. Cases were compared to a control group non-exposed to DILI using propensity score-derived inverse probability weights. Patients with DILI due to alcohol or paracetamol were excluded from analysis.
Results: Seventy-two cases of DILI admitted to hospital were identified. Antimicrobials caused 56.9% of cases, with amoxicillin-clavulanate the single most common agent, responsible for 13.9% of cases. DILI cohort median age (50.2±36 years) was significantly younger than controls (65.0±38 years) (P},
issn = {2415-1289}, url = {https://tgh.amegroups.org/article/view/5665}
}