@article{TGH4694,
author = {Joshua K. Kays and Jeffrey D. Sohn and Bradford J. Kim and Katherine Goze and Leonidas G. Koniaris},
title = {Approach to wild-type gastrointestinal stromal tumors},
journal = {Translational Gastroenterology and Hepatology},
volume = {3},
number = {0},
year = {2018},
keywords = {},
abstract = {Gastrointestinal stromal tumors (GISTs) arise from the intestinal pacemaker cells of Cajal. Wild-type gastrointestinal stromal tumors (WT-GIST) are a unique and uncommon subtype of GISTs that lack activating mutations in the tyrosine kinase c-KIT or platelet derived growth factor receptor alpha (PDGFRA) receptors. The lack of these growth-stimulating mutations renders tyrosine kinase receptor inhibitors, such as imatinib mesylate, relatively ineffective against these tumors. WT-GIST arises most commonly due to underlying alternate proliferative signals associated with germ-line, genetic mutations. WT-GIST frequently arises in patients with BRAF mutations, Carney’s Triad or neurofibromatosis type-1 (NF-1). All patients with WT-GIST require a careful examination for germ-line mutations and very close observation for recurrent tumors. Surgery remains a mainstay therapy for these patients. This review aims to discuss the most recent data available on the diagnosis and treatment of WT-GIST.},
issn = {2415-1289}, url = {https://tgh.amegroups.org/article/view/4694}
}